Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties.
Hadi RajabiNur KonyalilarSinem ErkanDeniz MortazaviSeval Kubra KorkuncOzgecan KayalarHasan BayramReza RahbarghaziPublished in: Stem cell research & therapy (2022)
Chronic obstructive pulmonary disease (COPD) is known as the third leading cause of human death globally. Enhanced chronic inflammation and pathological remodeling are the main consequences of COPD, leading to decreased life span. Histological and molecular investigations revealed that prominent immune cell infiltration and release of several cytokines contribute to progressive chronic remodeling. Recent investigations have revealed that exosomes belonging to extracellular vesicles are involved in the pathogenesis of COPD. It has been elucidated that exosomes secreted from immune cells are eligible to carry numerous pro-inflammatory factors exacerbating the pathological conditions. Here, in this review article, we have summarized various and reliable information about the negative role of immune cell-derived exosomes in the remodeling of pulmonary tissue and airways destruction in COPD patients.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- mesenchymal stem cells
- stem cells
- pulmonary hypertension
- cystic fibrosis
- end stage renal disease
- newly diagnosed
- endothelial cells
- oxidative stress
- single cell
- ejection fraction
- chronic kidney disease
- air pollution
- healthcare
- induced pluripotent stem cells
- patient reported outcomes
- social media
- health information