p53-Induced Autophagy Regulates Chemotherapy and Radiotherapy Resistance in Multidrug Resistance Cancer Cells.
Shumei MaDejuan KongXinxin FuLin LiuYi LiuChang XueZhujun TianLan LiXiao Dong LiuPublished in: Dose-response : a publication of International Hormesis Society (2021)
Our discovery found that p53 is an important regulator controlling the balance between autophagy and MDR, as a potential drug target for ovarian cancer and leukemia.
Keyphrases
- cell death
- endoplasmic reticulum stress
- locally advanced
- oxidative stress
- signaling pathway
- diabetic rats
- early stage
- drug induced
- high glucose
- small molecule
- multidrug resistant
- acute myeloid leukemia
- radiation therapy
- bone marrow
- transcription factor
- high throughput
- rectal cancer
- squamous cell carcinoma
- radiation induced
- endothelial cells
- human health
- risk assessment
- electronic health record
- stress induced