Childhood maltreatment and risk of endocrine diseases: an exploration of mediating pathways using sequential mediation analysis.

Shu WenJianwei ZhuXin HanYuchen LiHaowen LiuHuazhen YangCan HouShishi XuJunren WangYao HuYuanyuan QuDi LiuThor AspelundFang FangUnnur A ValdimarsdóttirHuan Song

Published in: BMC medicine (2024)

Our study demonstrates that adverse psychological sequel of childhood maltreatment constitutes the main pathway to multiple endocrine diseases, particularly type 2 diabetes and HPA-axis-related endocrine diseases. Therefore, increased access to evidence-based mental health services may also be pivotal in reducing the risk of endocrine diseases among childhood maltreatment-exposed individuals.

Keyphrases

type diabetes
early life
cardiovascular disease
glycemic control
childhood cancer
skeletal muscle
emergency department
weight loss
insulin resistance
data analysis
adverse drug
drug induced