NFAT control of immune function: New Frontiers for an Abiding Trooper.

Published in: F1000Research (2018)

Nuclear factor of activated T cells (NFAT) was first described almost three decades ago as a Ca 2+/calcineurin-regulated transcription factor in T cells. Since then, a large body of research uncovered the regulation and physiological function of different NFAT homologues in the immune system and many other tissues. In this review, we will discuss novel roles of NFAT in T cells, focusing mainly on its function in humoral immune responses, immunological tolerance, and the regulation of immune metabolism.

Keyphrases

nuclear factor
toll like receptor
immune response
transcription factor
gene expression
protein kinase