Glycemia and Gluconeogenesis with Metformin and Liraglutide: A Randomized Trial in Youth-onset Type 2 Diabetes.
Katrina B DietscheSheela N MaggeSydney A DixonFaith S DavisAndrea KrenekAruba ChowdhuryLilian MabundoMichael StaglianoAmber B CourvilleShanna YangSara TurnerHongyi CaiKannan KasturiArthur S ShermanJoon HaEileen ShouppeMary WalterPeter J WalterKong Y ChenRobert J BrychtaCody PeerYi ZengWilliam FiggFran CogenD Elizabeth EstradaShaji ChackoStephanie T ChungPublished in: The Journal of clinical endocrinology and metabolism (2023)
Among Y-T2D, metformin with or without liraglutide improved glycemia but did not suppress high rates of gluconeogenesis. Novel therapies that will enhance β-cell function and target the elevated rates of gluconeogenesis in Y-T2D are needed.