Unexplained exertional intolerance associated with impaired systemic oxygen extraction.

Kathryn H MelamedMário SantosRudolf K F OliveiraMariana Faria UrbinaDonna FelsensteinAlexander R OpotowskyAaron B WaxmanDavid M Systrom

Published in: European journal of applied physiology (2019)

We identified a cohort of patients whose exercise limitation is due only to systemic oxygen extraction, due to either an intrinsic abnormality of skeletal muscle mitochondrion, limb muscle microcirculatory dysregulation, or hyperventilation and left shift the oxyhemoglobin dissociation curve.

Keyphrases

skeletal muscle
end stage renal disease
newly diagnosed
chronic kidney disease
prognostic factors
insulin resistance
high intensity
physical activity
type diabetes
metabolic syndrome
heat stress
patient reported outcomes
adipose tissue
resistance training