Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers.

Juhi OjhaIryna DyagilStuart C FinchRobert F ReissAdam J de SmithSemira GonsethMi ZhouHelen M HansenAmy L SherborneJean NakamuraPaige M BracciNataliya GudzenkoMaureen HatchNataliya BabkinaMark P LittleVadim V ChumakKyle M WalshDimitry BazykaJoseph L WiemelsLydia B Zablotska

Published in: Environmental health : a global access science source (2018)

No significant enrichment in copy-number abnormalities at CLL-associated genes was identified in UR-CLL compared to other groups. The novel associations between radiation exposure, telomere maintenance and CLL prognosis identified in this unique case series provide suggestive, though limited data and merit further investigation.

Keyphrases

chronic lymphocytic leukemia
copy number
mitochondrial dna
genome wide
dna methylation
big data
gene expression
high resolution
radiation therapy
deep learning
data analysis
bioinformatics analysis