Addition of the Aβ42/40 ratio to the cerebrospinal fluid biomarker profile increases the predictive value for underlying Alzheimer's disease dementia in mild cognitive impairment.
Inês BaldeirasIsabel SantanaMaria João LeitãoHelena GensRui PascoalMiguel Tábuas-PereiraJosé Beato-CoelhoDiana DuroMaria Rosário AlmeidaCatarina Resende OliveiraPublished in: Alzheimer's research & therapy (2018)
Our results confirm the usefulness of the CSF Aβ42/40 ratio in the interpretation of CSF biomarker profiles in MCI patients, by increasing the proportion of conclusive profiles and enhancing their predictive value for underlying AD.