Effects of metformin on tumor hypoxia and radiotherapy efficacy: a [18F]HX4 PET imaging study in colorectal cancer xenografts.

Sven De BruyckerChristel VangestelSteven StaelensLeonie WyffelsJan DetrezMarlies VerschuurenWinnok H De VosPatrick PauwelsTim Van den WyngaertSigrid Stroobants

Published in: EJNMMI research (2019)

Metformin decreased [18F]HX4 uptake of Colo205-tumors, but had no additive effect on radiotherapy efficacy. Nevertheless, [18F]HX4 holds promise as a prognostic imaging biomarker.

Keyphrases

pet imaging
early stage
locally advanced
radiation therapy
radiation induced
high resolution
squamous cell carcinoma
computed tomography
rectal cancer
mass spectrometry
artificial intelligence