Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.

Grace M LloydJess-Karan S DhillonKimberly-Marie M GorionCara RiffeSusan E FromholtYuxing XiaBenoit I GiassonDavid R Borchelt

Published in: Molecular neurodegeneration (2021)

These studies reveal novel and unexpected interplays between α-synuclein pathology, Aβ and neuroinflammation in mice that recapitulate the pathology of Alzheimer's disease and Lewy body dementia.

Keyphrases

mouse model
cognitive impairment
mild cognitive impairment
cognitive decline
traumatic brain injury
parkinson disease
lipopolysaccharide induced
genome wide
single cell
lps induced
type diabetes
case control
cerebral ischemia
inflammatory response
wild type
insulin resistance
blood brain barrier