Production and analysis of multiply charged negative ions by liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry.
Oliver J HalePavel RyuminJeffery M BrownMichael MorrisRainer CramerPublished in: Rapid communications in mass spectrometry : RCM (2018)
Negative ion mode is a sensitive alternative to positive ion mode in liquid AP-MALDI MS analysis. In particular, the analysis of lipids and DNA benefited from the complementarity of the detected lipid species and the vastly greater DNA ion signal intensities in negative ion mode.