Multiple Dietary Vitamin K Forms Are Converted to Tissue Menaquinone-4 in Mice.
Jessie L EllisXueyan FuJ Philip KarlChristopher J HernandezJoel B MasonRussell A DeBose-BoydSarah L BoothPublished in: The Journal of nutrition (2021)
Dietary PK, MK4, MK7, and MK9 all served as precursors to tissue MK4 in mice. This study expands our understanding of vitamin K metabolism and supports a common conversion mechanism of all dietary vitamin K forms to MK4. Further investigation of the metabolism and physiological roles of MK4 that may be independent of classical vitamin K function are warranted.
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