Evaluation of bi-directional causal association between depression and cardiovascular diseases: a Mendelian randomization study.

Gloria Hoi-Yee Li Ching-Lung CheungAlbert Kar-Kin ChungBernard Man-Yung CheungIan Chi-Kei WongMarcella Lei Yee FokPhilip Chun-Ming AuPak-Chung Sham

Published in: Psychological medicine (2020)

Genetic predisposition to depression may have positive causal roles on CAD/MI. Genetic susceptibility to self-awareness of mood problems may be a strong causal risk factor of CAD/MI. Blood lipid levels and smoking may potentially mediate the causal pathway. Prevention and early diagnosis of depression are important in the management of CAD/MI.

Keyphrases

coronary artery disease
sleep quality
depressive symptoms
cardiovascular disease
genome wide
mental health
bipolar disorder
copy number
smoking cessation
type diabetes
gene expression
physical activity
cardiovascular events