Methylation Analyses Reveal Promoter Hypermethylation as a Rare Cause of "Second Hit" in Germline BRCA1-Associated Pancreatic Ductal Adenocarcinoma.

Binbin Zheng-LinMichael RainoneAnna M VargheseKenneth H YuWungki ParkMichael BergerMiika MehineJoanne ChouMarinela CapanuDiana MandelkerZsofia K StadlerOzge BirsoySowmya JairamCiyu YangYirong LiDonna WongJamal K BenhamidaMarc LadanyiLiying ZhangEileen M O'Reilly

Published in: Molecular diagnosis & therapy (2022)

In patients with gBRCA1-P/LPV-PDAC, loss of heterozygosity is the main inactivating mechanism of the wild-type BRCA1 allele in the tumor, and methylation of the BRCA1 promoter is a distinctly uncommon occurrence.

Keyphrases

dna methylation
genome wide
wild type
breast cancer risk
gene expression
transcription factor
risk assessment
oxidative stress