Gene rearrangements in consecutive series of pediatric inflammatory myofibroblastic tumors.
Elena V PreobrazhenskayaAglaya G IyevlevaAmina M SuleymanovaVladislav I TiurinNatalia V MitiushkinaIlya V BizinAlexandr O IvanstovOlga A GorustovichKseniya V ShelekhovaDenis Y KachanovSvetlana R VarfolomeevaVitaliy Y RoschinAnna N KazakovaDmitriy V LitvinovTatiana V ShamanskayaNikita A SavelovEvgeny N SuspitsinEvgeny N ImyanitovPublished in: Pediatric blood & cancer (2020)
Twenty-four of 29 IMTs (83%) were shown to have druggable rearrangements involving tyrosine kinases, 20 of these 24 gene fusions were detectable by simple and inexpensive PCR assay, which is based on the detection 5'/3'-end unbalanced gene expression.