Quantitative analysis of pulmonary vasculature in systemic sclerosis at spirometry-gated chest CT.

Mariaelena Occhipinti Cosimo BruniGianna CamiciottoliMaurizio BartolucciSilvia Bellando-RandoneAnna BassettoGiovanna CuomoDilia GiuggioliGiulia CiardiAlessio FabbrizziSara TomassettiFederico LavoriniMassimo PistolesiStefano ColagrandeMarco Matucci-Cerinic

Published in: Annals of the rheumatic diseases (2020)

Chest CT in SSc detects a progressive increase in PVV/LV as DLco decreases. Redistribution of perfusion to less affected lung regions rather than angiogenesis nearby fibrotic lung may explain the results. Further studies to ascertain whether the increase in PVV/LV reflects a real increase in blood volume are needed.

Keyphrases

systemic sclerosis
interstitial lung disease
contrast enhanced
image quality
computed tomography
dual energy
multiple sclerosis
magnetic resonance imaging
endothelial cells
magnetic resonance
vascular endothelial growth factor
idiopathic pulmonary fibrosis
lung function
case control