Quantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia.
Rebecca L MillerDhruva D DhavaleJennifer Y O'SheaKristin M AndruskaJialu LiuErin E FranklinChandana BuddhalaSusan K LoftinJohn R CirritoRichard J PerrinNigel J CairnsMeghan C CampbellJoel S PerlmutterPaul T KotzbauerPublished in: Annals of clinical and translational neurology (2022)
LBD is associated with insoluble α-syn accumulation in neocortical regions, but the relatively low neocortical levels in some cases suggest that other changes contribute to impaired function, such as loss of neocortical innervation from subcortical regions. The correlation between Aβ and α-syn accumulation suggests a pathophysiologic relationship between these two processes.