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Application of Adipose Stem Cells in 3D Nerve Guidance Conduit Prevents Muscle Atrophy and Improves Distal Muscle Compliance in a Peripheral Nerve Regeneration Model.

Cristian TrâmbițașBogdan Andrei CordoșDorin Constantin DorobanțuCristian VintilăAlexandru Petru IonTimea PapDavid CameliaClaudiu PuiacEmil-Marian ArbănaşiClaudiu Constantin CiucanuAdrian Vasile MureșanAlexandra-Cristina MunteanuEliza Russu
Published in: Bioengineering (Basel, Switzerland) (2024)
Our study demonstrates that the combination of 3D NGC and ASC increases the process of nerve regeneration and significantly improves the compliance and mechanical characteristics of muscle tissue distal to the injury site in a PNI murine model.
Keyphrases
  • peripheral nerve
  • stem cells
  • skeletal muscle
  • minimally invasive
  • adipose tissue
  • insulin resistance
  • type diabetes
  • mouse model
  • nlrp inflammasome
  • bone marrow