Cerebrospinal Fluid and Plasma Amine Profiles in Interictal Migraine.
Gerrit L J OnderwaterRobin M van DongenAmy C HarmsRonald ZielmanWillebrordus P J van OosterhoutJan B van KlinkenJelle J GoemanGisela M TerwindtArn M J M van den MaagdenbergThomas HankemeierMichel D FerrariPublished in: Annals of neurology (2022)
L-Arginine was decreased in the CSF (but not in plasma) of interictal patients with migraine with or without aura, and associated pathways were altered. This suggests that dysfunction of nitric oxide signaling is involved in susceptibility to getting migraine attacks. ANN NEUROL 2023.