Clinically-relevant Germline Variants in Children with Non-Medullary Thyroid Cancer.
Karin van der TuinDina RuanoJeroen KnijnenburgRob B van der LuijtHans MorreauThera P LinksFrederik J Hesnull nullPublished in: The Journal of clinical endocrinology and metabolism (2024)
The reported prevalence (13%) of germline variants in well-known tumor predisposing genes and the added value of a revised personal-/family history and histology led us to recommend genetic counseling for all childhood NMTC patients.The detected tumor predisposition syndromes are associated with a risk for second cancers which necessitates additional surveillance of the index patients and pre-symptomatic genetic testing of at risk family members.