High-dimensional analysis defines multicytokine T-cell subsets and supports a role for IL-21 in atopic dermatitis.
Tali CzarnowickiHyun Je KimAxel Patrice VillaniJacob W GlickmanEster Del DucaJoseph HanAna B PavelBrian H LeeAdeeb H RahmanMiriam MeradJames G KruegerEmma Guttman-YasskyPublished in: Allergy (2021)
A multicytokine signature characterizes moderate-to-severe AD, possibly explaining partial therapeutic responses to one cytokine targeting, particularly in severe patients. Prominent IL-21 signature in blood and skin hints for a potential pathogenic role of IL-21 in AD.