Single Construct Suppression and Replacement Gene Therapy for the Treatment of All CALM1 -, CALM2 -, and CALM3 -Mediated Arrhythmia Disorders.

Samantha K HamrickC S John KimDavid J Tester Manuela Gencarelli Kathryn E TobertMartina GluscevicMichael J Ackerman

Published in: Circulation. Arrhythmia and electrophysiology (2024)

CaM-mediated long-QT syndrome induced pluripotent stem cell-derived CM lines. The single CALM-SupRep construct may be able to treat all calmodulinopathies, regardless of which of the 3 CaM-encoding genes are affected.

Keyphrases

gene therapy
high glucose
diabetic rats
genome wide
case report
oxidative stress
endothelial cells
gene expression
atrial fibrillation
combination therapy
smoking cessation