Integrated analysis of transcriptomic and proteomic alterations in mouse models of ALS/FTD identify early metabolic adaptions with similarities to mitochondrial dysfunction disorders.

Anna MatveevaOrla WattersAni RukhadzeNiraj KhemkaDebora GentileIvan Fernandez PerezIrene Llorente-FolchCliona FarrellElide Lo CacciatoJoshua JacksonAntonia PiazzesiLena WischhofIna WoodsLuise HalangMarion HoggAmaya Garcia MuñozEugène T DillonDavid MatallanasIngrid ArijsDiether LambrechtsDaniele BanoNiamh M C ConnollyJochen H M Prehn

Published in: Amyotrophic lateral sclerosis & frontotemporal degeneration (2023)

Together, our unbiased integrative analyses unveil novel molecular components that may influence mitochondrial homeostasis in the earliest phase of ALS.

Keyphrases

amyotrophic lateral sclerosis
mouse model
oxidative stress
single cell
rna seq
single molecule