Identification of NUDT15 gene variants in Amazonian Amerindians and admixed individuals from northern Brazil.
Juliana Carla Gomes RodriguesTatiane Piedade de SouzaLucas Favacho PastanaAndré Maurício Ribeiro Dos SantosMarianne Rodrigues FernandesPablo PintoAlayde Vieira WanderleySandro José de SouzaJosé Eduardo KrollAdenilson Leão PereiraLeandro MagalhãesLaís Reis das MercêsAmanda Ferreira VidalTatiana Vinasco-SandovalGiovanna Chaves CavalcanteJoão Farias GuerreiroPaulo Pimentel de AssumpçãoÂndrea Ribeiro-Dos-SantosSidney SantosNey Pereira Carneiro Dos SantosPublished in: PloS one (2020)
Our findings indicate that Amerindian and admixed populations from northern Brazil have high frequencies of the NUDT15 haplotypes that alter the metabolism profile of thiopurines.