Rigidity in Parkinson's disease: Evidence from biomechanical and neurophysiological measures.

Although rigidity is a cardinal motor sign in patients with Parkinson's disease (PD), the instrumental measurement of this clinical phenomenon is largely lacking, and its pathophysiological underpinning remains still unclear. Further advances in the field would require innovative methodological approaches able to measure parkinsonian rigidity objectively, discriminate the different biomechanical sources of muscle tone (neural or visco-elastic components), and finally clarify the contribution to objective rigidity exerted by neurophysiological responses which have been previously associated with this clinical sign (i.e., the long-latency stretch-induced reflex). Twenty patients with PD (67.3 ± 6.9 years) and 25 age- and sex-matched controls (66.9 ± 7.4 years) were recruited. Rigidity was measured clinically and through a robotic device. Participants underwent robot-assisted wrist extensions at 7 different angular velocities randomly applied, when ON therapy. For each value of angular velocity, several biomechanical (i.e., elastic, viscous and neural components) and neurophysiologic measures (i.e., short- and long-latency reflex and shortening reaction) were synchronously assessed and correlated with the clinical score of rigidity (i.e., Unified Parkinson's Disease Rating Scale - part III subitems for the upper limb). The biomechanical investigation allowed us to measure objective rigidity in PD and estimate the neuronal source of this phenomenon. In patients, objective rigidity progressively increased along with the rise of angular velocities during robot-assisted wrist extensions. The neurophysiological examination disclosed increased long-latency reflexes, but not short-latency reflexes nor shortening reaction, in PD compared with controls. Long-latency reflexes progressively increased according to angular velocities only in patients with PD. Lastly, specific biomechanical and neurophysiological abnormalities correlated with the clinical score of rigidity. Objective rigidity in PD correlates with velocity-dependent abnormal neuronal activity. The observations overall (i.e., the velocity-dependent feature of biomechanical and neurophysiological measures of objective rigidity) would point to a putative subcortical network responsible for objective rigidity in PD which requires further investigation.