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Interactions of Cyclodextrins and their Hydroxyl Derivatives with Etodolac: Solubility and Dissolution Enhancement.

Wesam W MustafaMouhamad KhoderHamdy AbdelkaderRichard SingerRaid Alany
Published in: Current drug delivery (2023)
Superior dissolution enhancements of ETO were recorded for the FD mixture (up to 90% dissolved in less than 10 min). In conclusion, γ- and hydroxypropyl γ-derivative of cyclodextrins can be considered a promising excipient for enhancement of dissolution rates concerned for ETO.
Keyphrases
  • capillary electrophoresis
  • mass spectrometry
  • water soluble