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Diet-induced metabolic and immune impairments are sex-specifically modulated by soluble TNF signaling in the 5xFAD mouse model of Alzheimer's disease.

Maria Elizabeth De Sousa RodriguesMacKenzie L BolenLisa Blackmer-RaynoldsNoah SchwartzJianjun ChangMalú Gámez TanseyTimothy Robert Sampson
Published in: bioRxiv : the preprint server for biology (2024)
HFHC diet triggers metabolic and inflammatory dysregulation in 5xFAD miceAβ42 and Aβ40 increase in the CNS of male 5xFAD mice fed a HFHC diet.SolTNF inhibition partially reverts HFHC diet-induced metabolic and inflammatory dysregulation in male, but not female, 5xFAD mice.
Keyphrases
  • mouse model
  • physical activity
  • high fat diet induced
  • weight loss
  • oxidative stress
  • rheumatoid arthritis
  • type diabetes
  • blood brain barrier
  • wild type
  • insulin resistance
  • skeletal muscle