Diet-induced metabolic and immune impairments are sex-specifically modulated by soluble TNF signaling in the 5xFAD mouse model of Alzheimer's disease.
Maria Elizabeth De Sousa RodriguesMacKenzie L BolenLisa Blackmer-RaynoldsNoah SchwartzJianjun ChangMalú Gámez TanseyTimothy Robert SampsonPublished in: bioRxiv : the preprint server for biology (2024)
HFHC diet triggers metabolic and inflammatory dysregulation in 5xFAD miceAβ42 and Aβ40 increase in the CNS of male 5xFAD mice fed a HFHC diet.SolTNF inhibition partially reverts HFHC diet-induced metabolic and inflammatory dysregulation in male, but not female, 5xFAD mice.