Diet-induced metabolic and immune impairments are sex-specifically modulated by soluble TNF signaling in the 5xFAD mouse model of Alzheimer's disease.

Maria Elizabeth De Sousa RodriguesMacKenzie L BolenLisa Blackmer-RaynoldsNoah SchwartzJianjun ChangMalú Gámez TanseyTimothy Robert Sampson

Published in: bioRxiv : the preprint server for biology (2024)

HFHC diet triggers metabolic and inflammatory dysregulation in 5xFAD miceAβ42 and Aβ40 increase in the CNS of male 5xFAD mice fed a HFHC diet.SolTNF inhibition partially reverts HFHC diet-induced metabolic and inflammatory dysregulation in male, but not female, 5xFAD mice.

Keyphrases

mouse model
physical activity
high fat diet induced
weight loss
oxidative stress
rheumatoid arthritis
type diabetes
blood brain barrier
wild type
insulin resistance
skeletal muscle