Does Pain at an Earlier Stage of Chondropathy Protect Female Mice Against Structural Progression After Surgically Induced Osteoarthritis?

Isabell S von LogaVicky BatchelorClare DriscollAnnika BurleighShi-Lu L ChiaBryony StottJadwiga Miotla-ZarebskaDavid RileyFrancesco Dell'AccioTonia L Vincent

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

We confirm strong structural joint protection in female mice that is not due to activity or intrinsic repair differences. Female mice develop pain at the same time as males, but induce a distinct set of neurotrophins. We speculate that heightened pain sensitivity in female mice protects the joint by preventing overuse.

Keyphrases

chronic pain
high fat diet induced
pain management
neuropathic pain
type diabetes
rheumatoid arthritis
wild type
metabolic syndrome
adipose tissue
knee osteoarthritis
skeletal muscle