Activation of T Lymphocytes with Anti-PDL1-BiTE in the Presence of Adipose-Derived Mesenchymal Stem Cells (ASCs).

Leila Moeinzadeh Amin Ramezani Fereshteh Mehdipour Mahsa Yazdanpanah-Samani Mahboobeh Razmkhah

Published in: BioMed research international (2023)

Overall, anti-PDL1-BiTE selectively depletes PDL1pos cells and represents a new immunotherapeutic approach. It would increase the accumulation of T cells and can improve the prognosis of PDL1pos cancers in spite of the immunomodulatory effects of ASCs and C.M.

Keyphrases

induced apoptosis
cell cycle arrest
adipose tissue
insulin resistance
signaling pathway
cell death
young adults
pi k akt