Clinical Outcome-Related Mutational Signatures Identified by Integrative Genomic Analysis in Nasopharyngeal Carcinoma.

Wei Dai Dittman Lai-Shun ChungLarry Ka-Yue ChowValen Zhuoyou YuLisa Chan Lei Merrin Man-Long LeongCandy King-Chi ChanJosephine Mun-Yee Ko Maria Li Lung

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Our study highlights importance of defects of DNA repair machinery in nasopharyngeal carcinoma pathogenesis and their prognostic values for clinical implications. These signatures will be useful for patient stratification to evaluate conventional and new treatment for precision medicine in nasopharyngeal carcinoma.

Keyphrases

dna repair
dna damage
genome wide
dna damage response
oxidative stress
dna methylation
combination therapy
replacement therapy
smoking cessation