IL-4 drastically decreases deuterosomal and multiciliated cells via alteration in progenitor cell differentiation.

Hyung-Ju ChoYoun Wook ChungSungmin MoonJu Hee SeoMiran KangJae Sung NamSang Nam LeeChang-Hoon KimAugustine M K ChoiJoo-Heon Yoon

Published in: Allergy (2023)

The effects of IL-4 appear to be mediated through the loss of the deuterosomal population, resulting in the reduction in multiciliated cells. This study also newly suggests cell-specific markers that might be pivotal for investigating respiratory inflammatory diseases.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
single cell
cell death
stem cells
cell therapy
bone marrow
cell proliferation
respiratory tract