Clinical impact of recombinant thrombomodulin administration on disseminated intravascular coagulation due to severe acute cholangitis (Recover-AC study).
Takeshi OguraTakaaki EguchiKazunari NakaharaYoshihide KannoShunsuke OmotoMasahiro ItonagaTaira KurodaAkitoshi HakodaSeitaro IkeokaMegumi TakagiAkihiko OkadaJunya SatoRyo MoritaYousuke MichikawaKei ItoShinsuke KoshitaMamoru TakenakaMasayuki KitanoMitsuhito KoizumiKazuhide HiguchiPublished in: Journal of hepato-biliary-pancreatic sciences (2021)
In conclusion, rhTM seemed to improve patient survival, but future studies should only include patients with benign or malignant disease and should be performed according to APACHE II scores.