Dominant dystrophic epidermolysis bullosa is associated with glycolytically active GATA3+ Th2 cells which may contribute to pruritus in lesional skin.

Wilson Jr F AalaPing-Chen HouYi-Kai HongYu-Chen LinYu-Rong LeeWei-Ting TuMarieta PapanikolaouNatashia Benzian-OlssonAlexandros OnoufriadisHans I-Chen HarnDaw-Yang HwangSiao Muk ChengKurt Q LuPeng-Chieh ChenJohn A McGrath Chao-Kai Hsu

Published in: The British journal of dermatology (2024)

Single-cell RNA-seq helps define an enhanced DDEB-associated Th2 profile and rationalizes drug repurposing of anti-Th2 drugs in treating DDEB pruritus.

Keyphrases

rna seq
single cell
induced apoptosis
high throughput
cell cycle arrest
atopic dermatitis
transcription factor
endoplasmic reticulum stress
wound healing
oxidative stress
signaling pathway
cell death
electronic health record
drug discovery