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Combination of nicotinamide mononucleotide and troxerutin induces full protection against doxorubicin-induced cardiotoxicity by modulating mitochondrial biogenesis and inflammatory response.

Ahmad Jamei KhosroshahiBehnaz MokhtariReza Badalzadeh
Published in: Molecular biology reports (2022)
These findings shed new light on the understanding of additive properties of NMN/TXR combination therapy in protecting against DOX-induced cardiotoxicity. The cardioprotective effect of this combination therapy may be mediated in part through the restoration of mitochondrial function/biogenesis associated with the PGC-1α/NRF1/TFAM pathway, and suppression of inflammatory response.
Keyphrases
  • combination therapy
  • inflammatory response
  • oxidative stress
  • diabetic rats
  • high glucose
  • lipopolysaccharide induced
  • lps induced
  • drug induced
  • toll like receptor
  • drug delivery
  • skeletal muscle
  • stress induced