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Enantioselective N-Heterocyclic Carbene-Catalyzed Kinetic Resolution of Anilides.

Jianbo BieMing LangJian Wang
Published in: Organic letters (2018)
The N-heterocyclic carbene (NHC)-catalyzed enantioselective kinetic resolution of anilides (a kind of hemiaminals) is reported. Upon exposure to the reaction in the presence of an NHC precatalyst and base, catalytic C-O bond formation occurs, providing axially chiral isoindolinones in high yields with excellent enantioselectivities.
Keyphrases
  • room temperature
  • single molecule
  • ionic liquid
  • electron transfer
  • crystal structure