Selection-driven cost-efficiency optimization of transcripts modulates gene evolutionary rate in bacteria.

Published in: Genome biology (2018)

This analysis provides a simple mechanistic explanation for variation in evolutionary rate between genes that depends on selection-driven cost-efficiency optimization of the transcript. These findings reveal how optimization of resource allocation to messenger RNA synthesis is a critical factor that determines both the evolution and composition of genes.

Keyphrases

genome wide
dna methylation
genome wide identification
copy number
bioinformatics analysis
single cell
gene expression
rna seq
transcription factor