Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation.

Alex M JaegerLauren StopferMin-Jung Lee Giorgio Gaglia Demi A Sandel Sandro SantagataNancy U LinJane B TrepelForest WhiteTyler JacksSusan LindquistLuke Whitesell

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

These highly translatable observations support reconsideration of the most effective strategy for targeting HSP90 to treat cancers and suggest a practical approach to repurposing current orally bioavailable HSP90 inhibitors as a new immunotherapeutic strategy.See related commentary by Srivastava and Callahan, p. 6277.

Keyphrases

heat shock protein
heat shock
heat stress
cancer therapy
amino acid
oxidative stress
binding protein
drug delivery
young adults
small molecule