Quantitative measurement of peritumoral concentrations of glutamate, N-acetyl aspartate, and lactate on magnetic resonance spectroscopy predicts glioblastoma-related refractory epilepsy.

Yawara NakamuraAkihiro InoueMasahiro NishikawaTakanori OhnishiHajime YanoYonehiro KanemuraYoshihiro OhtsukaSaya OzakiKosuke KusakabeSatoshi SuehiroDaisuke YamashitaSeiji ShigekawaHideaki WatanabeRiko KitazawaJunya TanakaTakeharu Kunieda

Published in: Acta neurochirurgica (2022)

Extracellular concentrations of glutamate, N-acetylaspartate, and lactate in the tumor periphery were significantly elevated in patients with GBM with refractory seizures. Measurement of these metabolites on MRS may predict refractory epilepsy in such patients and could be an indicator for continuing the use of antiepileptic drugs.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
ms ms
temporal lobe epilepsy
patient reported