Olfactory Dysfunction Mediates Adiposity in Cognitive Impairment of Type 2 Diabetes: Insights From Clinical and Functional Neuroimaging Studies.
Zhou ZhangBing ZhangXin WangXin ZhangQing X YangZhao QingWen ZhangDalong ZhuYan BiPublished in: Diabetes care (2019)
Obese subjects with type 2 diabetes showed impaired cognition and dysfunctional olfaction and brain networks, the latter of which mediated adiposity in cognitive impairment of diabetes. GLP-1Ras ameliorated cognitive and olfactory abnormalities in obese subjects with diabetes, providing new perspectives for early diagnosis and therapeutic approaches for cognitive decrements in these patients.
Keyphrases
- type diabetes
- cognitive impairment
- glycemic control
- insulin resistance
- cardiovascular disease
- end stage renal disease
- adipose tissue
- weight loss
- metabolic syndrome
- ejection fraction
- chronic kidney disease
- white matter
- newly diagnosed
- peritoneal dialysis
- prognostic factors
- oxidative stress
- weight gain
- mild cognitive impairment
- resting state
- obese patients
- multiple sclerosis
- patient reported outcomes
- functional connectivity
- subarachnoid hemorrhage
- case control