A Molecular Dynamic Simulation, Structural Analysis, and Ex Vivo Insights into the P-glycoprotein-Mediated Interactions of Dietary Polyphenols with Cyclin-dependent Kinase Inhibitors: A Potential Strategy to Counteract Drug Efflux.

Prajakta Harish Patil Mrunal Pradeep Desai Vullendula Sai Krishna Anand Rajdeep Ray Gurupur Gautham Shenoy Swapnil Jayant Dengale Krishnamurthy Bhat Puralae Channabasavaiah Jagadish

Published in: Current medicinal chemistry (2024)

The study emphasizes the significance of curcumin and quercetin as inhibitors of P-glycoprotein, demonstrating their potential to decrease the efflux of palbociclib and ribociclib, consequently contributing to their bioavailability enhancement.

Keyphrases

cell cycle
human health
single molecule
cell proliferation
cell death
signaling pathway
adverse drug
cell cycle arrest