Xenobiotic Exposure and Migraine-Associated Signaling: A Multimethod Experimental Study Exploring Cellular Assays in Combination with Ex Vivo and In Vivo Mouse Models.

Rikke H RasmussenSarah L ChristensenKirstine CalloeBrian Skriver NielsenAnders RehfeldThomas E Taylor-ClarkKristian A HaanesOlivier TaboureauKarine AudouzeDan A KlaerkeJes OlesenDavid M Kristensen

Published in: Environmental health perspectives (2023)

Here we show that multiple environmental pollutants interact with the TRPA1-CGRP migraine pain pathway. The data provide valuable insights into how environmental chemicals can interact with neurobiology and provide a potential mechanism for putative increases in migraine prevalence over the last decades. https://doi.org/10.1289/EHP12413.

Keyphrases

human health
mouse model
chronic pain
risk factors
pain management
electronic health record
risk assessment
life cycle
big data
machine learning
climate change
deep learning
artificial intelligence