Effect of CD14/TLR4 antagonist on GnRH/LH secretion in ewe during central inflammation induced by intracerebroventricular administration of LPS.

Karolina HaziakAndrzej Przemysław HermanKarolina WojtulewiczBartosz PawlinaKamila PaczesnaJoanna BochenekDorota Tomaszewska-Zaremba

Published in: Journal of animal science and biotechnology (2018)

It was indicated that blockade of TLR4 prevents the inhibitory effect of centrally acting LPS on the GnRH/LH secretion. This suggests that some negative effects of bacterial infection on the hypothalamic-pituitary-gonadal axis activity at the hypothalamic level may be caused by central action of LPS acting through TLR4.

Keyphrases

inflammatory response
toll like receptor
anti inflammatory
immune response
oxidative stress
nuclear factor
mouse model