PRL-R variants are not only associated with prolactinomas but also with dopamine agonist resistance.

Andrea Ramos de Castro MoreiraEricka TrarbachCristina Bellotti Formiga BuenoAnna Louise Stellfeld MonteiroIsabella Pacetti Pajaro GrandeMario PadulaGustavo Arantes Rosa MacielAndrea Glezer

Published in: The Journal of clinical endocrinology and metabolism (2023)

The PRL/PRL-R system seems to be related to prolactinoma tumorigenesis and cabergoline resistance. Additional studies are needed to better understand the PRL-R variants' role and their potential as therapeutic targets.

Keyphrases

copy number
gene expression
dna methylation
prefrontal cortex