Microfractures, autologous matrix-induced chondrogenesis, osteochondral autograft transplantation and autologous chondrocyte implantation for knee chondral defects: a systematic review and network meta-analysis of randomized controlled trials.
Silvia ValisenaBenjamin AzoguiRémy S NizardPhilippe M TschollEtienne CavaignacPierre-Alban BouchéDidier HannouchePublished in: EFORT open reviews (2024)
This NMA showed no difference for PROMs with any technique. The lower failure and reoperation rates with chondrospheres must be interpreted with caution since adverse event data was heterogenous among trials. The standardization of the efficacy and safety outcome measures for future trials on knee cartilage repair and regeneration is necessary.
Keyphrases
- anterior cruciate ligament reconstruction
- total knee arthroplasty
- platelet rich plasma
- cell therapy
- patient reported outcomes
- bone marrow
- knee osteoarthritis
- stem cells
- anterior cruciate ligament
- systematic review
- high glucose
- diabetic rats
- electronic health record
- current status
- big data
- drug induced
- endothelial cells
- adverse drug
- emergency department
- mesenchymal stem cells
- machine learning
- deep learning