Metabolism-based isolation of invasive glioblastoma cells with specific gene signatures and tumorigenic potential.

Stuart James SmithJonathan RowlinsonMaria Estevez-CebreroDavid OnionAlison RitchiePhil ClarkeKatie WoodMohammed DiksinAnbarasu LourdusamyRichard Guy GrundyRuman Rahman

Published in: Neuro-oncology advances (2020)

Identification of unique molecular features in the invasive GBM population offers hope for developing more efficacious targeted therapies compared to targeting the tumor core and for isolating tumor subpopulations based upon intrinsic metabolic properties.

Keyphrases

induced apoptosis
cell cycle arrest
cancer therapy
copy number
dna methylation
gene expression
oxidative stress
risk assessment
cell death
drug delivery
cell proliferation
human health