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Homozygous mutations in CCDC34 cause male infertility with oligoasthenoteratozoospermia in humans and mice.

Jiangshan CongXiong WangAmir Amiri-YektaLingbo WangZine-Eddine KherrafChunyu LiuCaroline CazinShuyan TangSeyedeh Hanieh HosseiniShixiong TianAbbas DaneshipourJiaxiong WangYiling ZhouYuyan ZengShenmin YangXiao-Jin HeJinsong LiYunxia CaoLi JinPierre F RayFeng Zhang
Published in: Journal of medical genetics (2021)
Our findings support that CCDC34 is crucial to the formation of sperm flagella and that biallelic deleterious mutations in CCDC34/Ccdc34 cause male infertility with oligoasthenoteratozoospermia in humans and mice.
Keyphrases
  • high fat diet induced
  • polycystic ovary syndrome
  • intellectual disability
  • insulin resistance
  • type diabetes
  • wild type
  • metabolic syndrome
  • adipose tissue