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Cofactors of wheat-dependent exercise-induced anaphylaxis do not increase highly individual gliadin absorption in healthy volunteers.

Katharina Anne ScherfAnn-Christin LindenauLuzia ValentiniMaria Carmen ColladoIzaskun García-MantranaMorten ChristensenDirk TomsitzClaudia KuglerTilo BiedermannKnut Brockow
Published in: Clinical and translational allergy (2019)
The adsorption of gliadin in the gut in healthy volunteers is less dependent on cofactors than has been hypothesized. Patients with WDEIA may have a predisposition needed for the additional effect of cofactors, e.g., hyperresponsive or damaged intestinal epithelium. Alternatively, other mechanisms, such as cofactor-induced blood flow redistribution, increased activity of tissue transglutaminase, or increases in plasma osmolality and acidosis inducing basophil and mast cell histamine release may play the major role in WDEIA.
Keyphrases
  • blood flow
  • celiac disease
  • high glucose
  • diabetic rats
  • endothelial cells
  • oxidative stress