Contributions of Gene Modules Regulated by Essential Noncoding RNA in Colon Adenocarcinoma Progression.
Chunhua LiXiaorong YuJianping LuLiyu ZhengDahua XuZelong XuLiqiang WangYing CuiYeshuang LiHong WangJiankai XuKongning LiPublished in: BioMed research international (2020)
Noncoding RNAs (ncRNAs), especially microRNA (miRNA) and long noncoding RNA (lncRNA), have an impact on a variety of important biological processes during colon adenocarcinoma (COAD) progression. This includes chromatin organization, transcriptional and posttranscriptional regulation, and cell-cell signaling. The aim of this study is to identify the ncRNA-regulated modules that accompany the progression of COAD and to analyze their mechanisms, in order to screen the potential prognostic biomarkers for COAD. An integrative molecular analysis was carried out to identify the crosstalks of gene modules between different COAD stages, as well as the essential ncRNAs in the posttranscriptional regulation of these modules. 31 ncRNA regulatory modules were found to be significantly associated with overall survival in COAD patients. 17 out of the 31 modules (in which ncRNAs played essential roles) had improved the predictive ability for COAD patient survival compared to only the mRNAs of those modules, which were enriched in the core cancer hallmark pathways with closer interactions. These suggest that the ncRNAs' regulatory modules not only exhibit close relation to COAD progression but also reflect the dynamic significant crosstalk of genes in the modules to the different malignant extent of COAD.
Keyphrases
- network analysis
- long noncoding rna
- transcription factor
- genome wide
- squamous cell carcinoma
- end stage renal disease
- gene expression
- genome wide identification
- chronic kidney disease
- newly diagnosed
- cell therapy
- stem cells
- peritoneal dialysis
- dna damage
- climate change
- case report
- prognostic factors
- dna methylation
- mesenchymal stem cells
- long non coding rna
- locally advanced