Elevated YKL-40 and low sAPPβ:YKL-40 ratio in antemortem cerebrospinal fluid of patients with pathologically confirmed FTLD.
Daniel AlcoleaDavid J IrwinIgnacio Illán-GalaLaia MuñozJordi ClarimónCorey T McMillanJuan ForteaRafael BlesaEdward B LeeJohn Q TrojanowskiMurray GrossmanAlberto LleóPublished in: Journal of neurology, neurosurgery, and psychiatry (2018)
Our study provides pathological confirmation that the combination of low sAPPβ and high YKL-40 in CSF is associated with FTLD. These biomarkers could be useful in particular clinical settings when FTLD is suspected.
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