Thymol Protects against 5-Fluorouracil-Induced Hepatotoxicity via the Regulation of the Akt/GSK-3β Pathway in In Vivo and In Silico Experimental Models.
Yasmen F MahranAmira M BadrLayla A AlkharashiHanaa N AlajamiNouf T AldamryNervana Moustafa BayoumyElshaymaa I ElmongySahar SolimanPublished in: Pharmaceuticals (Basel, Switzerland) (2024)
Our research is the first to shed light on thymol's potential protective effect against 5-FU- induced hepatotoxicity by inhibiting oxidative and apoptotic pathways and modulating the Akt/ GSK-3β as well as p44/42 MAPK (ERK1/2) signaling pathways.